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Paojilhuasca · Medicines

Amazonian Plants and Healing

Did you know that nearly 70% of Western pharmaceutical medicines trace their origins back to Amazonian plants?

For centuries, indigenous healers—known as curanderos—have carefully preserved and passed down the wisdom of these living medicines. Unlike Western science, which often isolates single compounds, Amazonian healing works with plants in their whole form, respecting their natural timing, balance, and synergy.

Our Approach

Our Carefully Curated Medicine Cabinet

We understand that the variety of medicines that we offer at our retreat may seem overwhelming. You will be gradually introduced to each medicine that we have available (eg. rapé and mambe on Day 1, kambo on Day 2, ayahuasca on Day 3, etc.) and have the support of our facilitators to teach you about the traditional use, help you with administration, brief you on expected effects, etc.

Just like a Western pharmacy, we keep different medicines for different individual needs. What works well for one individual may not be the best fit for another. Though you can freely access some of our non-psychedelic medicines (ie. mambe, rapé, and sananga), our facilitators and shamans will be there to provide guidance whenever needed.

No ceremony or activity is mandatory, and we may discourage participation from additional ceremonies (especially yopo and bufo) if you’re still processing strong experiences from earlier in the week. However, for someone who didn’t feel much during their prior ceremony, a medicine like yopo can provide an opportunity to receive potentially transformative insights from a different type of plant medicine.

In addition to the medicines described below, we very occasionally host San Pedro (Huachuma) ceremonies. These are typically offered during longer stays, depending on the desires and dynamics of the group. When held, they usually take place on Sundays with few or no arriving guests to ensure an uninterrupted environment.

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Our Medicines

Legend

The Legend of the Eagle and the Condor

The legend of the Eagle and the Condor comes from time immemorial and is spread throughout Central and South America: it speaks of two groups of people, those of the eagle’s lineage and those descended from the condor. The eagle represents the north, masculinity, rationality, and science. On the other hand, the people of the condor are intuitive, creative, sensitive and primordially connected to the female energy and the south. These two groups have competed with one another since the beginning of the time. This legend talks about cycles of time, Pachakuti, lasting 500 years.

The previous cycle started around 1490, the time of the European invasion of the Americas, and it finished around 1990. In this cycle, the People of the Eagle stood victorious, bringing a society based on rational thinking, industrialization, individualism, and masculine power. This Pachakuti corresponds with the time of repression of native cultures connected with mother nature. Since 1990, the people of the condor have started to rise again, looking for balance.

According to the legend, the time we are currently living is a time of reconciliation: feminine with masculine, intuition with rationality, individualism with collectivism. The legend also tells of a canoe of medicines moving through our time, bringing balance and harmony, where the ancestral medicines and spiritual practices of North and Central America will meet those of the South – combining the traditions of ancient medicines like ayahuasca, peyote, bufo, yopo, coca, magic mushrooms and San Pedro.

When used with wisdom and respect, the medicines of the North and the South can work together to bring balance to the people of our time. Following this idea, the Paojilhuasca Medicine Centre also works with shamans from Mexico, Colombia, and Brazil, and holds the medicines of various American regions to treat each individual in as holistic and personalized of a manner as possible.

Your Time in the Amazon Awaits

Give yourself the gift of time, space and quiet, surrounded by the primordial nature of the Peruvian Amazon, in careful hands.

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Medicines

Traditional Ayahuasca Ceremonies

Ayahuasca is a traditional Amazonian plant brew, used for centuries by Indigenous peoples across the Amazon basin in healing and spiritual ceremonies. Effects may include vivid visions, intensified emotions, altered perception of time and self, and often a purging response such as vomiting or diarrhea. Many people describe the experience as deeply introspective, bringing up memories, insights, or a sense of connection with nature and something larger than themselves.

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Ayahuasca preparation over a wood fireFreshly cut ayahuasca vines

Medicines

Kambo Treatment & Courses

Kambo is the secretion of the Amazonian giant monkey frog (Phyllomedusa bicolor), used since ancient times by Indigenous groups in the western Amazon basin. The frog venom is applied to small superficial burns made on the skin and was traditionally used in hunting preparation and ritual cleansing. The usual response is a rapid heart rate, facial flushing and swelling, nausea, vomiting and purging within minutes, with a feeling of calm or heightened alertness afterward. The entire experience typically lasts 20-30 minutes.

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Amazonian giant monkey frogClose-up of the kambo frog

Medicines

Mambé

Mambé is a traditional preparation made from the leaves of the coca plant, used by Indigenous communities in parts of the Amazon, including Peru and Colombia. Traditionally, the leaves are dried, finely ground and mixed with plant-based ashes to create a fine powder.

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Traditional Mambé powder and container

Medicines

Bufo

Bufo refers to the dried secretion of the Sonoran Desert toad (Incilius alvarius, also called Bufo alvarius), which contains 5-MeO-DMT, a fast-acting psychoactive tryptamine, along with bufotenin. In ceremonies, the dried secretion is vaporised and inhaled, and the effects arrive within seconds and usually last 15 to 30 minutes. People commonly describe an intense dissolving of the sense of self, overwhelming emotion, a feeling of unity or boundlessness, and little of the visual imagery associated with ayahuasca. Afterward, many report feeling calm, open, or emotionally lighter, and some use it for self-exploration and integration.

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Sonoran Desert toad (Incilius alvarius)

Medicines

Yopo

Yopo is a psychoactive snuff prepared from the seeds of the Anadenanthera peregrina tree, which contain bufotenin along with smaller amounts of DMT and 5-MeO-DMT. It is sometimes referred to as the “wild sister” of ayahuasca. The onset is rapid, typically within 5-15 minutes, and the effects relatively short, usually 1-1.5 hrs. Participants may experience physical discomfort, heat, and occasionally vomiting, alongside heightened sensory awareness, vivid imagery, and a strong sense of presence or clarity.

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Yopo seeds and ground preparation

Medicines

Sananga

The plant-based sananga eye drops—brewed from the Tabernaemontana genus of shrubs native to the upper Amazon—are said to enhance eyesight and have long been used by indigenous tribes to prevent and treat ocular diseases like glaucoma, cataracts, near-sightedness, and blindness. But sananga is also commonly used to treat skin diseases, infections, arthritis, cancer, and perhaps most interestingly, to clear a person of what is called panema—anxiety, depression, bad luck, negative energies, and laziness.

In fact, it’s by clearing this panema that sananga is said to promote overall eye health. As a shaman would explain it, sananga does its work not at the physical or cellular level but rather on an energetic level.

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Sananga shrub in flower

Medicines

Rapé

Its name comes from French and means “grated” (grated tobacco); its origin is ancient and it is prepared by shamans.

Rapé is a mixture of various Amazonian plants, roasted and ground, whose base is tobacco; Acre in Brazil is the place that has the greatest tradition in rapés and many varieties.

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Rapé preparations and traditional applicators

Medicines

Chinese Medicine

At Paojilhuasca, we integrate Traditional Chinese Medicine (TCM) practices—such as moxibustion, cupping, and Qigong (chikung)—alongside Amazonian ancestral medicine to support a holistic healing process. This fusion is not simply additive; it’s synergetic, drawing on different wisdom traditions to restore balance across physical, emotional, and energetic dimensions.

Ayahuasca can open powerful energetic and emotional processes, but for many participants, the body needs support to process what emerges. That’s where TCM comes in – it helps you explore the energy of your body and gently support the grounding of profound psychological experiences. The manner in which we involve TCM in our retreat has been slowly refined over time based on the experiences of real guests.

Moxibustion

This warming technique uses burning mugwort to stimulate acupoints, promoting circulation, warming meridians, and dispersing cold or stagnant energy. After ceremonies, it can stabilize the body’s vital energy (Qi) and help digest intense energetic movements triggered by the medicine.

Cupping

Cupping helps to release blockages, toxins, and emotional tension held in the body—especially in the back and shoulders. It facilitates detoxification and relieves muscular and energetic congestion, making space for the integration of insights received during ceremonies.

Qigong (Chikung)

Every morning, before breakfast, we begin with Qigong to awaken the body, harmonize the breath, and center the mind. This daily ritual cultivates presence, strengthens the nervous system, and prepares participants to face the deep work of ceremony with balance and clarity.

Ancestral and Eastern Synergy

Amazonian medicine often works through visions, purge, and spirit. TCM brings a systematic and embodied approach to balance and flow. Together, they offer a complementary map of health: one rooted in the rainforest, the other in the Tao.

In short, the use of TCM at Paojilhuasca is not an exotic add-on—it’s an intentional choice to support deep healing, to help participants stay grounded and present, and to cultivate long-term vitality after the peak experiences of ceremony.

Medicines

Breathwork: Conscious Connected Breathing

Breathwork can help prepare the mind and body for profound experiences, creating a safe and grounded foundation to explore deeper states of awareness. At Paojilhuasca we practice Conscious Connected Breathing, which is a modern breathwork technique developed in the 1970s by Leonard Orr, sharing roots with Stanislav Grof’s holotropic breathwork and older yogic pranayama traditions. It involves breathing in a continuous, circular rhythm with no pause between the inhale and exhale, usually through the mouth, for a sustained session guided by a facilitator and often paired with evocative music. Many guests experience strong emotional release, vivid imagery, deep relaxation, and a sense of clarity or altered awareness. The practice reduces carbon dioxide levels in the blood, which can also produce tingling in the hands and face, muscle tension or cramping in the hands, lightheadedness, and waves of energy or warmth.

We offer two hour-long sessions of Conscious Connected Breathing per week, on the days of our ayahuasca ceremonies. By scheduling breathwork the same day as ayahuasca ceremonies, we’ve seen that guests can sometimes get a sense of what themes or emotions might arise during that night’s ceremony. The self-pacing approach of breathwork enables guests to dive into emerging sensations as deep as they’re comfortable. After breathwork, guest often report feeling increased confidence and comfort heading into ceremony later that day.

A week on the Itaya River, in a small group, with time to slow down and listen. Diverse somatic practices to reconnect to your body, immerse yourself in nature’s beauty, and rediscover the medicine of authentic community. The whole time, be supported by our caring team – before, during, and after your stay. If you feel called, drop us a message and secure your place today.

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