5-MeO-DMT & Bufo alvarius – Key Findings

Rapid and lasting benefits: A single dose of 5-MeO-DMT (synthetic or Bufo alvarius secretion) has been shown to quickly reduce depression, anxiety, stress, and increase mindfulness and life satisfaction, with effects lasting weeks.

Clinical populations: Surveys show strong improvements in PTSD (79%), depression (77–80%), anxiety (69–79%), substance use (63%), and OCD (53%), with very few reports of worsening symptoms.

Clinical trials in Spain: Six hospitals (Barcelona, Madrid, Oviedo, Salamanca) ran Phase 2 trials using intranasal 5-MeO-DMT (BPL-003). Over 50% of patients with treatment-resistant depression improved within 24 hours, with effects lasting up to 85 days.

Main takeaway: 5-MeO-DMT is emerging as a fast-acting, well-tolerated psychedelic therapy, with outcomes linked to the depth of the mystical/ego-dissolution experience.